ON THE STRENGTH AND FRIABILITY OF SERIES PRODUCTS MANUFACTURED BY DIRECT COMPRESSION OF NON-METALLIC GRANULES
Keywords:
compression, strength, friability, tablets
Abstract
The aim Automation is essential in mass production. In the case of products obtained by direct compression of non-metallic powders, along with measures to increase productivity, there is a risk of reducing their quality. The present research represents an unconventional approach to the methodology of studying the friability of pharmaceutical tablets obtained by pressing the filling powders, in correlation with the working regime. The experiment used contributes to determining the impact of the compression cycles and the speed of the rotary table on the strength and friability of the tablets and other qualitative characteristics. The study enables the optimization of manufacturing technologies of pharmaceutical tablets, respecting the strict quality conditions imposed. The modernization of manufacturing technologies involves new approaches to scientific research in the field.
References
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25. Gordiienko O.I., Vronska L., Melnyk O.A., Groshovyi T.A. (2015), Сurrent state of creation, production and research of tablet medicinal products, Pharmaceutical Review, 1, https://doi.org/10.11603/2312-0967.2015.1.3780
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27. Tryhubchak O. (2018), Doslidzhennia optymalnykh umov vyhotovlennia tabletok kysloty atsetylsalitsylovoi z atorvastatynom, Liky Ukrainy, 2(35), pp. 7–10.
28. Trudko S.S., Gubenia O.O., Desyk M.G., Gavva O.M. (2024), Packaging of medicines in blister packs, Packaging, 3, pp. 28–31.
29. Oloniyon F. Akande, James L. Ford, Philip H. Rowe, Michael H. Rubinstein The Effects of Lag-time and Dwell-time on the Compaction Properties of 1: 1 ParacetamoUmicrocrystalline Cellulose Tablets Prepared by Pre-compression and Main Compression Journal of Pharmacy and Pharmacology, Volume 50, Issue 1, January 1998, Pages 19–28, https://doi.org/10.1111/j.2042-7158.1998.tb03300.x
2. Augsburger L.L., Hoag S.W. (2008), Pharmaceutical dosage forms - tablets, third edition, Taylor & Francis Grou.
3. Commission BP (2021), British pharmacopoeia 2021, Stationery Office.
4. Byrn S., Futran M., Thomas Hayden., Jayjock Eric., Maron Nicola., Meyer Robert., Myerson Allan., Thien Michael., Trout Bernhardt (2015), Achieving Continuous Manufacturing for Final Dosage Formation: Challenges and How to Meet Them. May 20–21, 2014 Continuous Symposium, Journal of Pharmaceutical Sciences, 104(3), pp. 792-802, https://doi.org/10.1002/jps.24247
5. CDER (Center for Drug Evaluation and Research) (2015), Guidance for industry: size, shape, and other physical attributes of generic tablets and capsules, United States Food and Drug Administration.
6. Çelik M. (2013), Pharmaceutical Powder Compaction Technology, CRC Press.
7. European pharmacopoeia. Available at: https://www.edqm.eu/en/web/edqm/european-pharmacopoeia.
8. ERWEKA GmbH (2024), TAR II - advanced friability and abrasion tester - ERWEKA GmbH. Home - ERWEKA GmbH. Available at: https://www.erweka.com/products/physical-testers/friability-tester.html
9. Etzler F.M., Bramante T., Deanne R., Sienkiewicz S., Chen F. J. (2011), Tablet tensile strength: an adhesion science perspective, Journal of Adhesion Science and Technology, 25(4–5), pp. 501–519, https://doi.org/10.1163/016942410X525687.
10. Giannis K., Schilde C., Finke J.H., Kwade A. (2021), Modeling of High-Density Compaction of Pharmaceutical Tablets Using Multi-Contact Discrete Element Method, Pharmaceutics, 13(12), 2194, https://doi.org/10.3390/pharmaceutics13122194
11. Goh H., Sia Heng P., Liew C. (2019), The effects of feed frame parameters and turret speed on mini-tablet compression, Journal of Pharmaceutical Sciences, 108(3), pp. 1161–1171, https://doi.org/10.1016/j.xphs.2018.09.005.
12. Goots V., Guts O., Gubenia O. (2016), Reodynamical theory of viscous-elastic system deforming, Proceedings of University of Ruse, 55(10.2), pp. 18-22.
13. Gubenia O., Goots O. (2010), Modeling of cutting of food products, Journal of EcoAgriTourism, 1, pp. 67–71.
14. Herasymenko D., Zomenko O., Gubenia O. Influence of tablet press rotor speed on tablet abrasion performance, 90th International scientific conference of young scientist and students "Youth scientific achievements to the 21st century nutrition problem solution", April 11–12, 2024, NUFT, Kyiv.
15. Natoli D., Levin M., Tsygan L, Liu L. (2017), Development, Optimization, and Scale-Up of Process Parameters, In: Developing Solid Oral Dosage Forms, Ed.: Yihong Qiu, Yisheng Chen, Geoff G.Z. Zhang, Lawrence Yu., Rao V. Mantri, pp. 917–951, https://doi.org/10.1016/B978-0-12-802447-8.00033-9.
16. Peeters E., Silva A.F.T., Fonteyne M., De Beer T., Vervaet C., Remon C. (2018), Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets, European journal of pharmaceutics and biopharmaceutics, 128, pp. 300–315, https://doi.org/10.1016/j.ejpb.2018.05.007.
17. Pharmaeducation (2024), Quality control tests of tablets or Evaluation of tablets, Available at: https://pharmaeducation.net/quality-control-tests-of-tablets-or-evaluation-of-tablets/.
18. Pitt K., Heasley M. (2013), Determination of the tensile strength of elongated tablets, Powder technology, 238, pp. 169–175, https://doi.org/10.1016/j.powtec.2011.12.060.
19. Podczeck F. (2007), Methods for the practical determination of the mechanical strength of tablets – From empiricism to science, International journal of pharmaceutics, pp. 214–232, https://doi.org/10.1016/j.ijpharm.2012.06.059.
20. Salawi A. (2022), Pharmaceutical coating and its different approaches, a review. Polymers, 14(16), pp. 3318, https://doi.org/10.3390/polym14163318
21. Siiriä S.M. Antikainen O., Heinämäki J., Yliruusi J. (2011), 3D simulation of internal tablet strength during tableting, AAPS PharmSciTech, 12(2), pp. 593–603, https://doi.org/10.1208/s12249-011-9623-0
22. Sinka I.C., Pitt K.G., Cocks A.C.F. (2007), Chapter 22. The strength of pharmaceutical tablets, Handbook of Powder Technology, 12, pp. 941–970, https://doi.org/10.1016/s0167-3785(07)12025-x
23. Swarbrick J. (2007), Encyclopedia of pharmaceutical technology: Volume 6, Taylor & Francis Group, 2007.
24. Tye C.K., Sun C., Amidon G.E. (2005), Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction, Journal of Pharmaceutical Sciences, 94(3), pp. 465–472, https://doi.org/10.1002/jps.20262
25. Gordiienko O.I., Vronska L., Melnyk O.A., Groshovyi T.A. (2015), Сurrent state of creation, production and research of tablet medicinal products, Pharmaceutical Review, 1, https://doi.org/10.11603/2312-0967.2015.1.3780
26. Sivetskyi V., Shvachko D. (2023), Presove obladnannia, KPI im. Ihoria Sikorskoho, Kyiv
27. Tryhubchak O. (2018), Doslidzhennia optymalnykh umov vyhotovlennia tabletok kysloty atsetylsalitsylovoi z atorvastatynom, Liky Ukrainy, 2(35), pp. 7–10.
28. Trudko S.S., Gubenia O.O., Desyk M.G., Gavva O.M. (2024), Packaging of medicines in blister packs, Packaging, 3, pp. 28–31.
29. Oloniyon F. Akande, James L. Ford, Philip H. Rowe, Michael H. Rubinstein The Effects of Lag-time and Dwell-time on the Compaction Properties of 1: 1 ParacetamoUmicrocrystalline Cellulose Tablets Prepared by Pre-compression and Main Compression Journal of Pharmacy and Pharmacology, Volume 50, Issue 1, January 1998, Pages 19–28, https://doi.org/10.1111/j.2042-7158.1998.tb03300.x
Published
2025-09-30
How to Cite
Gubenia, O., Zomenko, O., Samarchuk, S., & Mnerie, D. (2025). ON THE STRENGTH AND FRIABILITY OF SERIES PRODUCTS MANUFACTURED BY DIRECT COMPRESSION OF NON-METALLIC GRANULES. Nonconventional Technologies Review, 29(3). Retrieved from http://revtn.ro/index.php/revtn/article/view/532
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